As a result, calls for Track 3 applications are not guaranteed. Students may take advantage of customized clinical activities at NIH and partner institutions while in the research phase of training, capitalizing on the resources of the NIH clinical center, the largest research hospital in the world, and first-rate clinical resources at the Universities of Oxford and Cambridge.
Tuition and stipend benefits are offered to students who enroll at a participating medical school that receives MSTP funding on a competitive basis. For students enrolled in medical schools not receiving MSTP funding, opportunities are provided to apply for individual fellowships for both the MD and PhD phases of training. Bernhard Staresina. The laboratory investigates the interactions between episodic memory formation and brain dynamics during sleep.
What is the role of specific brain rhythms during sleep? Can we use sleep to experimentally control the extent of forgetting? Pamela Schwartzberg. Klaus Okkenhaug. The Phosphoinositide 3-kinases PI3Ks are a family of lipid kinases that control diverse signalling pathways affecting gene-transcription, cellular adhesion and trafficking, autophagy and metabolism via the generation of PIP3.
Identifying germline and somatic genetic interactions that are relevant to patient outcomes in cancer. Padma Sheila Rajagopal. We hypothesize that pan-cancer or breast-cancer-specific germline-somatic interactions will demonstrate associations with therapy in the metastatic setting.
To test this, we will compile reported a germline-somatic variant interactions from papers and b datasets with individual-level treatment information and test the associations between these interactions and treatment response in metastatic breast cancer.
Multisensory learning helps an individual learn through more than one sense. However, the underlying neural mechanism is unclear. In this study we aim to pursue this question in a spatial learning regime. We will record neural dynamics of the MEC using two-photon imaging approach when mice navigate in virtual environments, in which multisensory spatial information will be precisely delivered.
The goal of the project is to deeply understand how the neural response of the MEC contributes to multisensory learning. The formation of infectious HIV-1 particles requires the incorporation of Env glycoproteins during the assembly process, with Env mediating binding of newly released virions to target cells and subsequent entry via fusion between viral and target-cell membranes.
The interaction between the MA domain of Gag and gp41 of Env plays a central role in Env incorporation into virions and in the activation of Env fusion activity, yet this interaction remains poorly understood at the biochemical and structural levels. In addition, recent structures of the MA lattice in both immature and mature HIV-1 particles implicate a maturation-induced rearrangement of MA the lattice. This opens the possibility that MA-gp41 interactions are dynamic, and change during the maturation process.
Predictions regarding potential sites of MA-MA and MA-gp41 interactions obtained from these structural studies will be tested in Env incorporation and virus replication assays. This combination of structural, biochemical, and virological studies will help to elucidate the mechanism of Env incorporation into HIV-1 particles and the subsequent process of particle maturation. Human immunodeficiency virus type 1 HIV-1 is the causative agent behind acquired immunodeficiency syndrome AIDS that currently has no cure or vaccine.
While antiviral treatments are effective, the rise of drug-resistant strains has become a growing concern. This process is dependent on the viral capsid. The HIV capsid is a conical structure that houses the genomic material of the virus. It needs to be metastable in order to be protective while allowing timely disassembly termed uncoating to release its genome.
The dynamics of the capsid nuclear import and uncoating are still unknown and are modulated by host dependency and restriction factors. We aim to apply multi-imaging modalities to investigate uncoating and nuclear import of HIV. The viral core and host factors will be fluorescently tagged, and infection will be monitored from viral attachment to nuclear import.
The combination of these imaging techniques, paired with molecular biology and virology tools, will yield unparalleled knowledge of the HIV infection process within the native cells, providing the framework for development of novel therapeutics targeting HIV infection in the future. Sridhar Hannenhalli.
These projects involve non-trivial methods development as well as sophisticated data analysis but the focus is always on the biological question. Our lab is involved in several collaborations with immunologists and cancer biologists.
Martin Turner. Lymphocytes respond to infection by rapidly increasing and decreasing the expression of many genes in a highly regulated manner. This regulation requires the integration of transcription, mRNA decay and translation. We are only just beginning to understand how these processes are integrated with each other.
By combining structural and molecular biology approaches with cellular immunology and mouse models of immune responses we offer a broad training experience and the opportunity to discover fundamental mechanisms of gene regulation in the immune system. Turner, D. Saveliev, A. Raisch, T. Review the partnership descriptions to determine which pathway, partnerships, and online application form are most appropriate for your admission consideration. Stipend Information: The stipends for graduate students at the NIH are adjusted yearly; the level depends on prior research experience and number of years at NIH as a graduate student.
For details, see the Trainee Stipends page. Carefully review the information on the two pathways and associated partnership descriptions prior to creating a MyGPP account. Your MyGPP account will grant you access to one of the following applications, based on responses to specific questions about your educational status and intentions:. Graduate students come to the NIH in one of two ways: Institutional Partnerships - the pathway for students wishing to enroll in a PhD program Individual Partnership - the pathway for students already enrolled in a PhD program Eligibility : There are many NIH-University partnerships available to US citizens, US permanent residents, or international graduate students.
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